Exfoliants — like Retin-A — are an important part of any skincare regimen, whether for acne or general facial rejuvenation. However, not all exfoliants play well together. One of the more well-known culprits of not mixing well with others is Retin-A. More specifically, using Retin-A with other acids can easily cause this chemical to break or go inactive, which ultimately does not benefit your skin. Instead, consider switching up your skin care routine and applying products that don't mix well at different times of the day. That way, you can get the most out of your skin care products and avoid any unwanted skin reactions.